Processing and Secretion of Alzheimer's Disease Amyloid Precursor Protein

Abstract

KINBARA, K., KITAGAKI, H., KINOUCHI, T., OKANO, M., SORIMACHI, H., ISHIURA, S. and SUZUKI, K. Processing and Secretion of Alzheimers's Disease Amyloid Precursor Protein. Tohoku J. Exp. Med., 1994, 174 (3), 209-216 - We studied in vivo expression and in vitro secretion of the Alzheimer's disease amyloid precursor protein (APP). The results indicate that secretion of APP is mediated by PKC and the initial step of the processing may occur in the acidic secretooy granules of the glial cells. Our results suggest that a metabolic switch of APP in neural cells is critical in amyloid deposition.