The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
A Screening System for Antiviral Compounds against Herpes Simplex Virus Type 1 Using the MTT Method with L929 Cells
KENJI SUDO, KENJI KONNO, TOMOYUKI YOKOTA, SHIRO SHIGETA
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キーワード: herpes simplex virus, L929 cells, MTT assay
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1995 年 176 巻 3 号 p. 163-171

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SUDO, K., KONNO, K., YOKOTA, T. and SHIGETA, S. A Screening System for Antiviral Compounds against Herpes Simplex Virus Type 1 Using the MTT Method with L929 Cells. Tohoku J. Exp. Med., 1995, 176 (3), 163-171-We developed the improved MTT assay system for in vitro evaluation of anti-HSV-1 agents using L929 cells derived from mouse connective tissue. This assay system provides results in 4 days using a 96-well microplate. The EC50 values of several anti-HSV agents (ACV, BVaraU, and others) were found to be similar to those obtained by the plaque reduction method using MRC-5 cells. The present MTT assay is rapid, accurate, and may be useful as an automatic screening system for evaluation of anti-HSV-1 compounds.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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