Abstract
Guanidine hydrochloride and synthaline were administered to the rabbits, normal, doubly suprarenalectomized or doubly splanchnicotomized. The blood sugar concentration (determined by Hagedorn and Jensen), was systematically followed.
0.25 to 0.4 grm. guanidine hydrochloride per kilo was subcutaneously given to normal rabbits. In two thirds of the cases a hyperglycaemia occurred, and either lasted for several hours or was replaced sooner or later by the developing of a hypoglycaemic stage, and in the rest only a hypoglycaemia became manifest. The bilateral splanchnicotomy was capable of reducing this hyperglycaemic stage to some extent, and in the doubly suprarenalectomized rabbits no hyperglycaemia was observed on administering the drug in doses varying from 0.35 grm. to 0.15 grm. per kilo. Whether the later finding can be taken as occurring invariably seems to the present writer still open to question.
Synthaline was given in such a dose as to elicit invariably convulsive seizures, as 25 mgrms. to 12.5 mgrms. per animal and nearly always both the hyperglycaemic and hypoglycaemic phases were discovered. The double suprarenalectomy acted to diminish the hyperglycaemic reaction to some extent.
