抄録
Rabbits received insulin every day in doses of 0.1-1.5 units for about five weeks; 24-30 hours after the last injection the animals were killed for determining the epinephrine content by means of the SutoKojima's colorimetrical method. The splanchnic nerve was cut per laparotomiam several days before the first injection.
Both glands were found somewhat enlarged, and the gland with the intact innervation as involving a somewhat large amount of epinephrine. If it be reckoned on the gland weight no deviation from the normal was to be noted, but it is reasonable to take the total amount of epinephrine into account. The denervated gland contained a smaller amount of epinephrine compared with the normal; the present writer has no good grounds to decide whether to range it within the normal limits inherent in the denervated gland or to take it as abnormally smaller, that is as to the action of the repeated insulin administration upon the denervated gland in the long run. At any rate it is sure that the increase of the epinephrine load in the suprarenals due to a repeated insulin application depends upon the integrity of the innervation of the glands.
A previous finding, that an intravenous administration of insulin brings about a transitory increase of the epinephrine load, was confirmed by the present writer, although it is in a much smaller degree.
