Abstract
The upper cervical sympathetic ganglion was removed unilateral-ly in a number of dogs. They were cooled by means of cold water; the body temperature fell commonly to 30° or beneath. The pupil width and the blood sugar concentration were determined. Paradoxi-cal pupil reaction and hyperglycaemia invariably occurred. Then the suprarenal glands were bilaterally deprived of their medullary tissues. On cooling the paradoxical pupil reaction still occurred, but only on a largely diminished scale while hyperglycaemia of sufficient strength was brought about simultaneously. Then, the relation between the time elapsed after the ganglionectomy and the sensibility of the denervated pupil being taken into consideration, the removal of the suprarenal medulla was carried out before that of the upper cervical ganglion, and cooling was carried out from a few days to three weeks after the latter operation. The results were similar.
It may be therefore concluded that removal of the suprarenal me-dulla or abolishing the epinephrine secretion from the suprarenal glands, interferes largely with the paradoxical pupil dilatation due to cold stimulations to dogs, while it never significantly influences the hyperglycaemia.
