Abstract
Alpha lobelin was administered in rabbits, normal, doubly splanch-nicotomized or doubly suprarenalectomized, intravenously(3.5 mgrms. or 7 mgrms. per kilo of body weight) or subcutaneously (5 mgrms., 10 mgrms., or 20 mgrms. per kilo). The latter two kinds of animals were indefinitely surviving and quite healthy.
Double splanchnicotomy diminishes the hyperglycaemia causable by lobelin to some extent, but if a large amount be given, lobelin is capable of causing some distinct increase in the blood sugar concentration. If subcutaneously heavily dosaged, there are rather commonly two summits in the hyperglycaemic curve and they are of smallerheight.
Double suprarenalectomy is capable of causing the lobelin hyper-glycaemia of an insignificant degree only, and if largely dosaged there develops frequently the hypoglycaemic stage.
From these facts it is deducible that the suprarenals are almost indispensable in causing the hyperglycaemia by lobelin, which act also to increase the blood sugar through the central mechanism for the car-bohydrate metabolism, though not strongly so.
