Abstract
In the dogs, which were prepared for obtaining the suprarenal vein blood without fastening, narcotizing, laparotomizing or evoking pain, atropine was intravenously administered, which was followed by morphine or insulin. Epinephrine was estimated by means of the rabbit intestine segment.
The epinephrine output rate was accelerated, and the magnitude of acceleration nearly corresponds to that producible by those doses of morphine or insulin alone. Or at least the acceleration was not so large as to account for it as the sum of that elicitable by atropine and morphine or insulin, though it seemed somewhat likely with the latter.
At least we failed to gather any evidence of atropine inhibiting the acceleration in the epinephrine output rate due to morphine or insulin. This finding also stands against the view that only the parasympathetic nerve fibres control secretion of epinephrine from the suprarenal gland, and atropine paralyzes its termination, while the accelerating action of morphine and insulin upon the epinephrine discharge is annulled by splanchnicotomy.
