Periodic Occurrence of Methyl Glyoxal=like Substance in Human Milk and Periodic Weakening of Arakawa's Reaction. Influence of Menstruation upon Human Milk

110th Report of the Peroxidase Reaction

抄録

In a case of a healthy lactating woman, we had been examining the influence of a frequent administration of vitamin C in a large amount upon Arakawa's reaction of her milk.. It did not change in spite of a possibility that it might change the reaction from positive to negative in vivo too (as is the case in vitro). But suddenly it happened that the reaction became negative, to become again positive after a lapse of several days. We were able to identify a large amount of the methyl glyoxal like substance in her milk. During a long observation, such an incidence occurred three times with about one month's cycle. The second time she had a manifest menstruation and it became clear that she had a manifest menstruation once, and an occult menstruation the two other times.
In the case of an investigation into Arakawa's reaction of a lactating woman with positive reaction, we must take'into consideration the influence of an occult or manifest menstruation. Suppose we have given a large amount of ascorbic acid to her, just before a coming menstruation, then, we might attribute the negative Arakawa's reaction, which will occur due to the menstruation, to an administration of vitamin C, especially because this will, as this did really in our case, increase very much in the milk. Isono, one of us, proved that even a large amount of the vitamin C like substance in human milk cannot make Arakawa's reaction negative in a rather large number of cases.
As to the cause of negative Arakawa's reaction, it may be. due to a hypofunction of the liver which will be caused by the ovarial function at menstruation.