The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Studies on the Detoxicating Hormone of the Liver (Yakriton)
99th Report. Effect of Vitamin B1 Alone in a Single Dose and Vitamin B1 in Combination with Yakriton in a Single Dose in a Far Advanced Stage of Avitaminosis B1
Akira SatoHosaku Namekawa
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1944 Volume 46 Issue 3-4 Pages 241-251

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Abstract
A further experiment upon the effect of yakriton to intensify (or to mobilize or to save) vitamin B1 was performed. In a preceding paper Kimura reported that vitamin B used continuously in a certain amount cannot save animals in a far advanced stage of B1-avitaminosis unless aided by yakriton.
In the present paper vitamin B1 and yakriton were only once used in a far advanced stage of B-avitaminosis, and the comparison of effect was made between a single dose of vitamin B1 on one side and a single dose of it in com-bination of yakriton. This hormone intensified vitamin B1 and worked as if the vitamin had been used in an amount several times as large as the actual dose.
Yakriton has no vitamin B1 effect, but it is highly probable that in a far advanced stage of avitaminosis B1 vitamin Bl cannot be utilized to full extent due to the liver insufficiency (Cf. 73rd8) Report on Yakriton) caused by B1-avitaminosis. Yakriton mobilizes the vitamin to full extent and acts as if it saved the vitamin, so that such an effect of the hormone may well be called the vitamin mobilizing effect or the vitamin saving effect ofit.
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© Tohoku University Medical Press
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