The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Studies on Serum Antitrypsin
First Report. Inhibition Mechanism of Serum against Tryptic Proteolysis
Mitsuhisa Hayakawa
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1951 Volume 53 Issue 3-4 Pages 259-267

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Abstract
Through my experiments no difference could be noticed between serum and serum albumin with regard to their inhibition mechanism.
1. No difference can be observed between serum and serum albumin with regard to their inhibition mechanism against proteolysis.
2. Goldstein's theory3) is applicable to the substrate-trypsin-serum system, too.
3. In the inhibition of serum against tryptic proteolysis the reversible compound is formed, according to the law of mass action, between enzyme and inhibitor in serum.
4. I have built an equation representing these relations.
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