The Effect of Eserine upon the Accelerated Adrenaline Secretion Caused by KCl
1951 年 54 巻 3 号 p. 253-260
詳細
1951 年 54 巻 3 号 p. 253-260
In dogs, the suprarenal vein blood was collected without narcotizing. Adrenaline in the blood specimen was determined by means of the rabbit intestine segment method.
At first, 30-38mg per kg of KCl was injected intravenously in 15 seconds. After about half an hour, 0.3mg per kg eserine was injected intravenously in 60 seconds, and 4-11 minutes later KCl in a same dose was again injected. The adrenaline secretion after the second KCl injection was compared with that of the first KCl injection.
Before injection, the rate of adrenaline secretion from one gland was 0.02-0.03 γ per kg per min. At the first KCl injection, it increased to 0.22-0.57 γ per kg per min. After eserine, and before the second KCl injection, the rate of adrenaline secretion was 0.03-0.04 γ per kg per min. At the second KCl injection, it increased to 0.7-1.9 γ per kg per min.
Thus it is clear that the accelerating action of KCl upon the adrenaline secretion is enhanced by eserine.
