Abstract
1. 3 experiments in mice tuberculosis, the one with intraperitoneal injection of avian tubercle bacilli (Flemingo strain), and the other two with intravenous injection of human tubercle bacilli (H37Rv) were conducted.
In several stages after infection they were sacrificed and the macro-pathological findings were observed. The development of the disease, however, were chiefly judged by the cultivation test of the bacilli from lung, liver, spleen, lymph nodes and kidneys.
2. For the quantitative pursuance of the living bacilli, the resections of liver-pieces from the tuberculous mice were carried out repeatedly. The accidental death after this operation was not so often, the availability of this method being ascertained.
3. When Flemingo strain was injected intraperitoneally, the bacilli developed chiefly in livers, spleens and lymph nodes, but only little in lungs. Contrary to this intravenous injection of human tubercle bacilli caused the chief lesions in lungs and also in spleens. The natural healing tendency observed in the latter must be attended at the judgment of chemotherapeutic experiment.
In conclution, I wish to express my sincere appreciation to Prof. M. Kuroya for his continued encouragement.
