Studies on Mucopolysaccharide in Skin Diseases

I. Treatment of Urticaria Pigmentosa with Hyaluronidase

Abstract

As we had ascertained the existence of a quantity of hyaluronic acid in the histologically abundant mastcells of two cases of urticaria pigmentosa, by means of Lison's metachromatic staining, we applied injection of hyaluronidase in their involved skins interdermally or subcutaneously, and had the satisfaction of seeing both the cases cured to all intents. These results, we believe, may give some suggestions on the pathogenesis of this disease.