抄録
The present investigation was designed with the desire to know whether the active principles other than adrenaline and noradrenaline are presented in the adrenal medulla in a significant amount or not.
The medullary tissue of the bovine adrenal gland was extracted with trichloracetic acid. At first, the noradrenaline and adrenaline contents were estimated chemically by means of the permanganate method reported by Suzuki and Ozaki. The adrenaline-noradrenaline mixture was then prepared so as to contain just the same percentage of noradrenaline and adrenaline as the chemical estimates of the extract. Using this mixture as the standard the activity of the extract in three biologic tests was estimated quantitatively.
In five out of six specimens, the estimates obtainable by the three different methods were in every case almost similar each other. In one specimen, however, the estimate given by the blood pressure method was definitely smaller than those given by the intestine segment method and the pupil method.
Thus it can not yet be concluded that the active principles of the adrenal medulla are always soley two hormones, i.e. adrenaline and noradrenaline.
