Abstract
1. Epinephrine delivery in vivo causes augementation of the liver protease system on animals fasted for twenty four hours. But no change in protease activities is seen in vitro when epinephrine is directly added to liver homogenates.
2. Such phenomenon is observed in the absence of adrenal cortex but not observable on animals treated with epinephrine a short time after a meal.
3. Prior administration of glucose or alanin prevents epinephrine effect, i.e., no augmentation of protease system is seen.
4. Tryptic muscle proteolysis remains unaffected after epinephrine treatment.
5. The biological mechanism of gluconeogenesis is briefly discussed with enzyme augmentation phenomenon.
This work was carried out by a grant for development of scientific researches, given from the Ministry of Education. M. Hayakawa
