Effect of Blood Pressure Depressants on Plasma Proteins in Hypertensive Diseases
1956 年 64 巻 3-4 号 p. 231-241
詳細
1956 年 64 巻 3-4 号 p. 231-241
22 cases of essential hypertension (14 benign and 8 malignant), and 7 cases of nephritic hypertension (5 of chronic and 2 of acute glomeru-lonephritis) were injected intramuscularly with various blood pressure depressants, hexamethonium bromide (Methobromine), veratrum viride (Trapon) and 1-hydrazino-phthalazine (Apresoline), for effecting abrupt lowering of the blood pressure, and the protein fractions in the plasma before and after the blood pressure lowering were measured. The results are as follows:
1. The total plasma protein is slightly lower than the normal in all the hypertension forms, especially, in acute glomerulonephritis; upon lowering of blood pressure, the decrease is accentuated further in the hypertensions with disturbance of the renal function, being most marked in acute nephritis, followed by chronic nephritis and malignant essential hypertension. In benign essential hypertension, the value shows a very slight rise, if anything.
2. Albumin is reduced below the normal level in all forms of hyper-tension. Through lowering of the blood pressure, it is further diminished in the cases with renal damage, the reduction being marked in the order of malignant essential, chronic nephritic and acute nephritic hypertension. In benign essential hypertension, it tends to increase after the administra-tion of the depressants.
3. The total globulin content is augmented beyond normal in all the forms, fibrinogen and β- and γ-globulins being especially in increase, accordingly the ratio A/G being always subnormal. Upon effected lowering of blood pressure, α- and β-globulins decrease slightly, apparently in essential hypertension. Fibrinogen tends more or less to an increase in all cases, particularly marked in malignant essential and nephritic hyper-tension. γ-globulin is found significantly increased in essential hyper-tension, especially in malignant form; on the contrary in renal hyper-tension, it tends rather to decrease. After the blood pressure lowering, the ratio A/G increases towards normal value in benign essential hyper-tension, but is diminished further in all other forms.
4. It is mentionsworth that when the blood pressure is lowered immensely, even benign form may show changes similar to those in malig-nant and nephritic hypertension subjects.
5. No difference in results is observed by the use of different de-pressants.
6. An attempt is made to explain the pathologic physiology of the above presented findings. It is suggested that from the changes in the protein fraction picture of plasma certain functional disturbance of the important organs, such as kidney, brain, heart, liver and others, may be guessed and that some information on the evaluation of the blood pressure depressants can be obtained.
