Abstract
Seventeen male albino rats of the Lister strain were fed a diet containing 18% Japanese brewer's yeast as the sole source of dietary protein. One rat died of pneumonia. Eight rats (50%) died from massive hepatic necrosis after receiving the diet for 24 to 48 days (average:33 days). The chief histological changes in the livers of rats which died from hepatic necrosis were massive coagulative necrosis with fatty infiltration and hemorrhage. It is concluded that Japanese brewer's yeast may be relatively capable of producing dietary hepatic necrosis, for it may be deficient in cystine, α-tocopherol and Factor 3.
