Abstract
In the dogs, the dorsal spinal roots of the IV thoracic to the II lumbar cord of which were previously bilaterally divided, that is, the abdominal wall and the abdominal viscera were de-afferented, laevulose solution, in a dose of 2.5 grms. laevulose per kilo of body weight, was administered through the gastric tube into the stomach. The animal was fastened on the table; no narcotic was given, no pain was evoked by the operations. The introduction of laevulose was immediately followed by an increase of sugar content of the portal blood, which reached its maximum, in an half to one hour and then dropped to its initial height with about the same velocity as it ascended. In the later stage the hypoglycaemia was demonstrable.
This hyperglycaemia was pretty remarkable in the instances, where at the end of 8-9 hours' experiment after the administration only a small quantity of laevulose was left in the stomach, while it was not so evident, though unmistakable, when the passage of laevulose from the stomach into the intestine did not take place nearly so completely through the experimentation extended for many hours. In the latter examples the sugar content in the blood in the general circulation accordingly did not increase with certainty, in contrast to the former cases, where occurrence of hyperglycaemia was unquestionable in harmony with the remarkable increase of the reducing power in the portal blood.
The time relation of the hypenglycaemia was practically the same in both kinds of blood, that is the portal blood and the ear vein blood.
