The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Experimental Studies on Homologous Heart Transplantation
Second Report: Pharmacological Studies on the Transplanted Heart
神 文雄
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1960 年 72 巻 1 号 p. 24-29

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The cervical heart transplantation is a new and promising device for study of pharmacology of the denervated heart. In this experiments, pharmacological studies of vasopressants, central nervous stimulants and parasympathetic drugs on the denervated heart are studied in comparison with the recipient heart in the same body.
1. As a technique for investigating the denervated heart, the usefulness of the cervical heart transplantation described by Mann, Priestley, Marcowitz and Yater was proved.
2. Highsensitivity of the denervated heart to sympathomimetic drugs was found to be in the order of epinephrine, ephedrine and nor-adrenaline.
3. On the contrary, parasympathetics evoked no highsensitivity of the denervated heart.
4. Central nerve stimulants have no action on the denervated heart.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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