Abstract
1. Eighty-six compounds were screened for their local activity in eliciting cutaneous calcinosis in rats pretreated with dihydrotachysterol.
2. Alkali and alkali earth metals, as well as non-metallic elements when given as their common inorganic anion of sodium or potassium salts, were not active in producing cutaneous calcinosis.
3. Most metal elements, except alkali and alkali earth metal elements were active; but their effect seemed to depend on the specific characteristics of the elements themsevles.
4. Iron as a cation was one of the most active elements in eliciting cutaneous calcinosis.
