1964 Volume 83 Issue 3 Pages 282-307
Transperitoneal implantation of mouse ascites hepatoma MH 134, and transperitoneal or transurethral implantation of rat ascites tumor, Yoshida sarcoma and AH 130, were performed on the urinary bladder of the same strain animals, and following results were obtained. The bladder tumor was developed in high rate with the transperitoneal implantation, while it was produced in the rate of 27.3-54.5% with the transurethral method. The tumor cell was at first embedded in the mucosal layer, then infiltrated with rapid multiplication along the vesical wall invading some contiguous tissues, and thus the typical bladder tumor was produced. The occurrence of ascites had showed some difference between the kinds of tumor cell implanted. And it was found in 25.6-50.0% of the case in which the transperitoneal implantation was performed, while there could not be found any ascites in the case with transurethral implantation. The hy-droureter was found in a half of the cases in which the implantation of tumor cell was performed, and the occurrence rate of it was rather correspondent to the duration after the implantation. And it was assumed that this reveal the invasion of the produced tumor upon the ureteral orifice just as in the clinical cases.
