Abstract
Tissue activator of the plasmin system is easily extracted into such high molar solutions as 1-2 M KSCN, KCl, KI or 30% sucrose, but not into physiological saline solution. A question, therefore, arises as to by what mechanism such activator can enter into the circulation. In order to clarify the activation mechanism of the plasmin system and to determine whether or not the tissue activator can enter into the circulation, fibrinolytic activity of blood obtained from the vasa efferentia of the uterus was determined and compared with that from the cubital vein.
A marked elevation of fibrinolytic activity was observed in blood from the vasa efferentia of the uterus. It was also found that the endometrial tissue activator extracted into KSCN solution was completely transferred to the physiological saline-soluble form after the Sephadex column chromatography.
Thosc findings may suggest one possible mechanism of entrance of the tissue activator into the circulation.
