抄録
The author studied electron-microscopically myocardial lesions in thiamine-deficient rats. The changes in the heart muscle were decrease in electron density of mitochondrial matrix, swelling and rupture of mitochondria, reduction and derangement of cristae, mitochondrial degeneration, enlargement and destruction of cisternae of sarcoplasmic reticulum, appearance of large vacuoles and disappearance of cross striation in the myofibril.
These findings suggested that the cardiac lesions in thiamine deficiency were caused by disturbance of energy production, intracellular conduction of excitation and myofibrillar relaxation, which resulted from the changes of mitochondria and sarcoplasmic reticulum.
