The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Host Resistance against Tumor and Cancer Autografts in Humans
Tsuguo Shikata
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1967 Volume 91 Issue 4 Pages 355-366

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Abstract
In recent years, the outcome of tumor-growth has increasingly been interpreterl from the tumor-host relationship. Some tumor-factors such as maligiianey, antigenicity of tumor, etc., contribute to determining the relation. Our immuxiological research on experimental and human cancers revealed appearance of cancer antigen and loss of organ specific antigen in cancer tissues. Several host factors may also contribute to host resistance, such as hormonal regulation. reticuloendotheiial activity, antibody titers, etc.
Among the above-mentioned factors, none can be independently indicative of the host resistance. The author's eperienee on cancer auto-transplantation shows that, although it does not promise a better prognosis, it is useful in the evaluation of the degree of relapse and metastasis of tumors in the abdominal cavity. The author believes that a safe and simple aid for the diagnosis of cancer relapse is offered by the auto-transplantation. Immunological aspect of tumors and its relationship to cancer auto-transplantation is also discussed.
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© Tohoku University Medical Press
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