1967 年 93 巻 2 号 p. 131-137
The hemolyzed erythrocytes were examined electron-microscopically in three cases of paroxysmal nocturnal hemoglobinuria (PNH), in which the diagnosis was established by their typical clinical courses and laboratory findings.
The methods of electron microscopic observation in this study were those of Matthes et al. and their modifications. Hemolyzed erythrocytes in PNH showed variable appearances. Some of them were, however, observed even in normal hemolyzed erythrocytes. The folds of erythrocyte membrane were recognized in almost all the cells. The surface of stroma was smooth, granular or patchy, and the precipitations of matrix had or had not taken place. In some of the cells from PNH patients, there were many round flecks up to 0.5μ, while they were only a few in number in normal hemolyzed cells. But the number of these cells was small even in PNH, and their significance is obscure.
