Abstract
By means of a dye dilution method using Indoevanine green as an indicator, measurements of splenic blood flow and circulation time were carried out on the control and ischemic spleens in the dog and on spleens of clinical cases of Banti's syndrome with fairly satisfactory results. Splenic blood volume, vascular resistance and O2 consumption were calculated from the splenic blood flow and circulation time. The results are summarized as follows: Blood flow of the ischemic spleen of the dog was found increased, as compared with the control. In human subjects, total splenic blood flow of the control cases was approximately 300ml/min, while it was markedly increased in all the cases of Banti's syndrome. Splenie blood flow per gram tissue, however, was decreased in this syndrome. Concerning the splenic blood volume, resistance and circulation time, there were obvious differences between the control and diseased spleens. Total O2 consump-tion of the Banti spleen was three to six times greater than that of the control. Oxygen consumption per gram tissue, however, was markedly decreased. It was concluded that the splenic tissue in Banti's syndrome was in a hypoxic state, which might play a role in the pathogenesis of this syndrome.
