The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Influence of High and Low Potassium Diet on the Sodium Retaining Effect of Desoxycorticosterone Acetate in Dogs
Toshio Nakajima
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1968 Volume 95 Issue 1 Pages 55-62

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Abstract

Despite various theories on the mechanism of the appearance of DOCA escape, the nature of this phenomenon still remains unknown. In this study the influence of a high or low potassium diet on the sodium retaining effect of DOCA was investigated in dogs.
A low potassium diet facilitated the appearance of DOCA escape, while a high potassium diet delayed its appearance. The rise of blood pH was facilitated by a low potassium diet and inhibited by a high potassium one. Based on these results, the change in blood pH appears to be one of the factors contributing to the development of DOCA escape.

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