Abstract
A study was made of the effect of single and combined administrations of mitomycin C (MMC) and prednisolone (PS) on respiration and glycolysis of Ehrlich ascites tumor cells in vitro, and the following results were obtained.
1) PS had no effect on respiration and glycolysis at concentrations below 0. 15mg/ml, but inhibited respiration and stimulated glycolysis at concentrations above 0. 75 mg/ml.
2) MMC inhibited endogenous respiration, but stimulated oxygen uptake when glucose was added as the substrate at concentrations above 0. 05mg/ml. It was clarified that MMC exerted an inhibitory effect on glycolysis and facilitated the pentose phosphate pathway.
3) The combined effects of MMC and PS were determined by the algebraical sum of both.
