Abstract
The fibrous tissue in the biopsied bone marrow was serially observed in 157 patients with hematological disorders. An increase of argyrophil fibers was demonstrated in acute and chronic leukemias, erythroleukemia, malignant lym-phomas, carcinoma with metastasis to the marrow, polycythemia vera and primary myelofibrosis. The increase of argyrophil fibers was generally correlated with the grade of proliferation of the hematopoietic cells and its duration. Argyrophil fibers were reduced in aplastic anemia.
