1969 年 98 巻 2 号 p. 155-169
A newly synthesized sulfonylurea, glyclopyramide (N-p-chlorobenzene sul-fonyl, N'-pyrrolidinourea) was administered for a long period in 72 diabetic patients, including 25 inpatients and 47 outpatients.
The therapeutic effect of glyelopyramide was good in 30 (79%) and fair in 4 of 38 patients of Group I, who had not been treated with any antidiabetic agents. Of 31 patients of Group II, who had not responded to another antidiabetics, 13 (48%) responded excellently and 10 (37%) fairly to the drug. Good control was achieved by glyclopyramide in 6 of the 7 diabetics of group III, who had been controlled by insulin less than 25 units daily. These results indicate that glyclopyramide gave good response in patients who had not been controlled by other oral antidiabe-tics, as well as in the patients treated initially with the drug, and that in some of insulin-requiring diabetes insulin could be replaced by glyclopyramide.
Glucose tolerance was improved after a long-term administration of glyclopyramide. Elevated serum total lipid or cholesterol was decreased by the treatment with glyclopyramide. Four patients showed minor side-effects in the gastrointestinal tract. It is proved that the administration of the drug for a long period did not produce any toxic effects on liver function and hemogram.
From this study it was concluded that glyclopyramide could be used success-fully and safely in the treatment of diabetes mellitus.
