西イリアンおよび東カリマンタンで感染したクロロキン耐性熱帯熱マラリア

抄録

Two cases of falciparum malaria resistant to chloroquine are reported. The first patient was infected in West Irian and the second patient in East Kalimantan. The chloroquine-resistance of the infecting parasite was confirmed by quantitative determina-tion of parasite count daily when 1, 500 mg or 2, 100 mg of chloroquine were given to the patient. The determination of chloroquine in the blood and urine confirmed that the drug was absorbed and reached sufficient plasma levels to eradicate chloroquine-sensitive P. falciparum. The erythrocyte contained several times more chloroquine than the plasma. The in vitro chloroquine-sensitivity test of the parasites revealed that they were as re-sistent as the Malayan Camp strain. The 50 percent maturation inhibition concentration of chloroquine against the two strains was 0.6 nM/m/ of whole blood. These clinical and laboratory studies indicated that the West Irian strain was RI and the East Kalimantan strain RII resistant to chloroquine.