直腸生検を中心とした日本住血吸虫症の研究
3 皮内反応閾値, 臨床的分析および臨床諸検査
1978 年 6 巻 1 号 p. 27-42
詳細
1978 年 6 巻 1 号 p. 27-42
The threshold dilution of positive skin test was analysed on the 217 subjected patients and followed up for several years. Clinical features and laboratory tests were statistically analysed on two skin-test positive groups, Group I (egg+ by rectal biopsy), II (egg-) and Group C (Control). Group III (skin test -, egg-) was not reasonable as the control, because many of them were treated for schistosomiasis previously. Therefore, the control was selected from the healthy persons in the non-endemic area by the physical and laboratory examination. Group IV (skin test-, egg+ ) was excluded from the analysis because of the small number.
I. The threshold value of positive skin test
1) It was markedly higher in the younger generation than in the older; it was higher generally in men than in women.
2) It decreased sharply in the Niridazole-treated group, while it was changeless or slowly decreased in the non-treated group during several years.
II. Clinical features
Analyses on the frequency of the patients in the endemic area, of the threshold dilution titer, the COP positivity and the stool examination supported that the intensity of the schistosomal infection decreased in such order as I>II>III.
1) The frequency of complications with the disease ranged as I>II>III in decreasing order.
2) The incidence of hypertension was in such order as I > II > C, and abnormalities on the chest film as I≅II>C.
3) The incidence of the prolonged QT and other abnormalities in ECG decreased in order as I>II>C.
4) The higher incidence of hepatomegaly was recognized in I than in II, whereas no such a case in C.
III. Laboratory tests
1) The incidence of abnormal liver function decreased in such order as I>II>C in each parameter.
2) The incidence of anemia and leucopenia decreased in order as I or II>C, and a hemopoietic dysfunction due to the disease was suspected.
3) The incidence of abnormality in serum K, Na and total cholesterol level ranged as I or II>C. The incidence of proteinuria was also in order as I or II>C.
Thus, it was clarified that clinical and metabolic disorders were significantly brought about due to schistosomiasis japonica.
