Abstract
We reported previously that soluble E-selectin (sE-selectin), an endothelial activation marker, could be used to predict cardiovascular events in subjects with type 2 diabetes mellitus (DM). We also reported that adhering to practical diabetes guidelines helps prevent such events. Hypothesizing that guideline adherence may be associated with a decline in sE-selectin concentration, we measured routine physical and biochemical data and sE-selectin in 392 subjects with type 2 DM having no history of cardiovascular disease. A multiple regression model indicated that sE-selectin concentration was independently positively related to body mass index (BMI) and HbA1c (JDS) but negatively to LDL-cholesterol (LDL-C) (F=6.61, p<0.01). Guidelines recommend HbA1c (JDS) of <6.5 %, blood pressure of <130/80 mmHg, and LDL-C of 120 mg/dl. Categorized by category number 0 or 1, 2, or 3, sE-selectin concentration declined significantly (p<0.01). sE-selectin concentrations were 73.3 ± 34.4 ng/ml for 0 or 1, 65.4 ± 34.2 ng/ml for 2, and 61.3 ± 25.9 ng/ml for 3. Guideline adherence may thus suppress endothelial activation and decrease sE-selectin concentrations-factors that could help minimize cardiovascular event incidence in those with type 2 DM.
