Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Search
Advanced search
OR
Browse
Search
Volume 54, Issue 12
Displaying 1-12 of 12 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Feature
Hypoglycemia-New Insights of Old Disorders
Original Article
Diagnosis, Treatment
  • Study on Concomitant Clinical Use of Biphasic Insulin Analog Preparation and Prelunch α-glucosidase Inhibitor
    Yasuo Kuroki, Mako Ikeno, Takashi Ohue, Hikaru Takeshita, Akihiro Maet ...
    2011 Volume 54 Issue 12 Pages 888-893
    Published: 2011
    Released on J-STAGE: January 27, 2012
    DOIhttps://doi.org/10.11213/tonyobyo.54.888
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We compared circadian blood glucose variation with or without prelunch α-glucosidase inhibitor (α-GI) in type 2 diabetes inpatients injected twice daily with a biphasic insulin analog preparation (30Mix) morning and evening. Those without α-GI use showed hyperglycemia after lunch, while those with α-GI use showed favorable glycemic control after lunch in addition to breakfast and dinner. Blood glucose levels after lunch decreased significantly from 266.8±35.5 mg/dl to 173.6±39.3 mg/dl in 17 inpatients in whom α-GI was first used concomitantly with the biphasic insulin analog preparation (p<0.0001) . HbA1c (JDS) also improved significantly from 7.42±0.7 % before α-GI addition to 7.13±0.7 % 1 month after α-GI addition (p<0.01) and the effect was maintained for 6 months with HbA1c of 7.10±0.7 % in 16 outpatients in whom α-GI was first added just before lunch. Results suggest that adding α-GI to the biphasic insulin analog preparation twice daily aids in managing postprandial blood glucose and is an effective therapeutic option in long-term glycemic control.
    View full abstract
    Download PDF (399K)
Pathophysiology, Metabolic Abnormalities, Complications
  • Association of Adherence to Practical Diabetes Guidelines with Serum Concentration Decline in Soluble Adhesion Molecule E-selectin
    Kazunari Matsumoto, Ai Haraguchi, Keiichiro Fujishima
    2011 Volume 54 Issue 12 Pages 894-898
    Published: 2011
    Released on J-STAGE: January 27, 2012
    DOIhttps://doi.org/10.11213/tonyobyo.54.894
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We reported previously that soluble E-selectin (sE-selectin), an endothelial activation marker, could be used to predict cardiovascular events in subjects with type 2 diabetes mellitus (DM). We also reported that adhering to practical diabetes guidelines helps prevent such events. Hypothesizing that guideline adherence may be associated with a decline in sE-selectin concentration, we measured routine physical and biochemical data and sE-selectin in 392 subjects with type 2 DM having no history of cardiovascular disease. A multiple regression model indicated that sE-selectin concentration was independently positively related to body mass index (BMI) and HbA1c (JDS) but negatively to LDL-cholesterol (LDL-C) (F=6.61, p<0.01). Guidelines recommend HbA1c (JDS) of <6.5 %, blood pressure of <130/80 mmHg, and LDL-C of 120 mg/dl. Categorized by category number 0 or 1, 2, or 3, sE-selectin concentration declined significantly (p<0.01). sE-selectin concentrations were 73.3 ± 34.4 ng/ml for 0 or 1, 65.4 ± 34.2 ng/ml for 2, and 61.3 ± 25.9 ng/ml for 3. Guideline adherence may thus suppress endothelial activation and decrease sE-selectin concentrations-factors that could help minimize cardiovascular event incidence in those with type 2 DM.
    View full abstract
    Download PDF (293K)
Health Service, Medical Economics
  • Analysis of the Trend of Diabetic Patients after Strengtheneing of Cooperation among Community Based Medicine
    Rieko Hirao, Yuya Fujishima, Mami Suzawa, Tadafumi Kajimoto, Haruhiko ...
    2011 Volume 54 Issue 12 Pages 899-905
    Published: 2011
    Released on J-STAGE: January 27, 2012
    DOIhttps://doi.org/10.11213/tonyobyo.54.899
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The eventual goal of diabetic community medicine is to efficiently combine clinics and provide equal-quality medical care to all subjects through annual diabetes-complication checkups and stringent glucose control. We began sending outpatients to local clinics in 2005 and conducting large-scale circulatory inspection in mild cases twice a year. We also worked to implement the clinical pass and clinic visits without outpatients having to make appointments. We found a decrease in the total visits per year of outpatients and also, to our surprise, the number of diabetic inpatients. The admission of new subjects and outpatients due to poor glucose control also decreased, presumably due to improved local clinic and outpatient department treatment. Although total medical expenses changed little, ensuring clinic and hospital cooperation through community medicine is expected to further minimize diabetes complications thanks to efficient therapy and clinic and hospital use.
    View full abstract
    Download PDF (469K)
Case Report
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top