抄録
Effect of xylitol and insulin on acetate metabolism was observed using alloxan diabetic rat liver slices.
Incorporation of acetate-2-14C into total lipid, total fatty acid, phospholipid and triglyceride fraction was decreased in alloxan diabetic rat liver slices, and was recovered by insulin administration in vivo.
Addition of insulin in vitro to liver slices of normal rat or diabetic rat administered with insulin in vivo caused decrease in acetate-2-14C incorporation into fatty acid fraction (and no effect on incorporation into phospholipid and triglyceride).
By the addition of xylitol in vitro, acetate-2-14C incorporation into total lipid, total fatty acid, phospholipid, triglyceride and sterol fractions was decreased to about half level. Xylitol-U-14C incorporation into total fatty acid was almost same level as acetate incorporation and also decreased to about half level by the addition of acetate.
From these results, it would be considered that insulin administration to alloxan diabetic rat have induced enzyme activities concerning with fatty acid synthesis in the liver, and that the addition of xylitol caused regulation in these metabolic flow in substrate level.
