抄録
Six brothers and sisters whose parents were diabetics were studied from the view points of glucose metabolism and ophthalmoscopic examinations including fluorescein fundus photography.
The followings are the results of the present investigation.
1) Results of 100 g oral glucose tolerance test showed that two of them were diabetic and four were borderline hyperglycemic. The response of serum IRI was low in cases with diabetic glucose tolerance curve, but there was no significant difference of serum IRI between in the borderline group and in the control group who had neither abnormal glucose tolerance nor family disposition of diabetes including obesity. The level of NEFA at fasting state was higher in all cases than that of normal control group, but the pattern of falling level of NEFA after glucose loading was similar to that of normal group except one case. There was no significant difference of the value of NEFA at fasting state in comparision with that of group who had similar glucose tolerance but had no family history of diabetes.
2) None of them had abnormal Ophthalmological findings through opthalmoscopic examination and photography by fundus camera, but abnormal fluorescent dots suggestive of pathological change of capillary bed were found in all by fluorescein fundus photography.
