1972 年 15 巻 4 号 p. 266-271
Two cases of children with maturity-onset type diabetes in the siblings of a 14 year-old boy and a 11 year-old girl were reported.
Their mother and maternal grandmother had been diabetic, but there was no history of diabetes on the paternal side.
They were tested and followed by oral glucose tolerance test every three months, and the blood sugar values and plasma insulin responses to glucose were observed.
The glucose intolerance became worse progressively, showing a slight fluctuation and finally developed into overt diabetes during the period of five and a half years.
A significant but delayed plasma insulin response was seen during the state of mild carbohydrate intolerance, but low insulin response was found during the state of severe carbohydrate intolerance. However, they responded to sulfonylureas.
They were the cases of maturity-onset type seen in the childhood.