糖尿病患者における成長ホルモン分泌動態に関する研究

アルギニン, ニコチン酸, グルコース静注負荷時の変動

抄録

Human growth hormone (HGH), FFA, I RI and blood glucose were determined during the intravenous infusion of arginine, nicotinic acid and glucose in diabetic, borderline and non-diabetic subecjts.
1. Single 1-arginine infusion (0.4g/kg) caused no change of HGH levels in 12 diabetic subjects.
2. Because of low response of HGH after single dose in diabetics, double arginine infusions (0.3g/kg at zero time and at 90 minutes) were given. 20 diabetic subjects showed slight change of HGH levels and the peak response of HGH was observed at 60 minutes after the start of the second infusion.
3. Maximum HGH value/basal HGH value after double arginine infusions was significatly smaller in diabetic subjects.
4. In 9 diabetic subjects, intravenous administration of nicotinic acid (100 mg x 2) caused no increase of HGH levels and significant decrease of the secondary rise of FFA.
5. Among 10 diabetic subjects who had glucose (0.5 g/kg) infusion for 3 minutes, 5 subjects showed marked rise of HGH levels.
6. HGH responses to double arginine infusions, nicotinic acid and glucose in borderline subjects were similar to the diabetic response pattern.
7. The first arginine infusion caused marked increase of HGH levels, but HGH response to the second arginine infusion was markedly reduced in 7 non-diabetic subjects.
These results of diabetics suggest some implication of the abnormality of HGH secretion in these states.