抄録
Diabetes mellitus and hypertriglyceridemia ferquently coexist and both have been known to be associated with the vascular disease. By analogy with the glucose tolerance test, fat tolerance tests have been used to detect latent abnormalities of lipid metabolism. In the present paper we have investigated an intravenous fat tolerance test utilizing the fat emulsion, 10% Intralipid, and reported its clinical application to the study of lipid metabolism in diabetes.
Serial changes in the serum levels of triglyceride (TG), free fatty acid (FFA), blood sugar, IRI and in the lipoprotein metabolism after intravenous infusion of Intralipid in 12 diabetics without fasting hypertriglyceridemia. The results were compared with those obtained from control subjects.
1) Fat infusion caused significantly higer TG responses in diabetics immediately after (p<0.02), at 30 (p<0.01) and 60 (p<0.02) minutes.
2) FFA rose greatly immediately after the infusion of fat and gradually decreased, but no differences were apparent in the FFA response between diabetics and control subjects.
3) Serum IRI and blood glucose values after the fat infusion remained unchanged.
4) Chylomicron increased maximally immediately after the fat infusion, while pre-β lipoprotein showed the highest response at 30 minutes.
These findings suggested a decreased fat tolerance in diabetics.
