1989 Volume 32 Issue 1 Pages 51-56
We studied the effect of CS-514 (Pravastin, Sankyo Co., Tokyo), a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on triglyceride turnover in male Wistar rats. We gave the rats drinking water containing 0.04% CS-514 for 14 days. The drug significantly reduced very-low-density lipoprotein (VLDL) triglyceride and cholesterol levels and also reduced plasma triglycerides in non-fasted rats, but did not reduce plasma cholesterol. Treated rats also had lower triglyceride secretion rates (TGSR) in the non-fasted state than control rats. When fasted overnight, no difference in TGSR was found between the two, nor did the drug reduce TGSR in hypertriglyceridemic rats given 10% sucrose in their drinking water. We conclude that CS-514, an inhibitor of cholesterol biosynthesis, suppresses VLDL-triglyceride secretion in non-fasted rats. However, this effect can be seen in neither fasted rats nor rats with sucrose-induced hypertriglyceridemia.
