1989 Volume 32 Issue 1 Pages 57-59
It has been reported in the USA and Korea since 1975 that Vacor®, rodenticide, containing N-3-pyridylmethyl N'-p-nitrophenyl urea causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor®-induced diabetes mellitus has yet to be clarified. The effect of Vacor®, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor® suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It was suspected that the suppression of insulin release from pancreatic islets by Vacor® may contribute to the pathomechanism of Vacor®-induced diabetes mellitus and that this suppression might not be related to cAMP anc C-kinase.
