Effects of Neonatal Administration of Monosodium Glutamate on Bone in Rats

抄録

It has been known that monosodium glutamate (MSG) treatment to neonatal rodents affects hypothalamic arcuate nucleus, the primary site of growth hormone releasing hormone, and consequently inhibits growth hormone release. However, there have been few reports on bone changes with aging after MSG treatment to neonatal rodents. Male and female neonatal F344 rats were subcutaneously given 4,000 mg/kg of MSG on days 0, 2, 4, 6, and 8 after birth, and the changes of the femurs were examined at 12 months of age. As a result, the bone length, diameters of the femur diaphysis and bone mineral density, especially the metaphysis region, were decreased by the treatment. Histologically, the amount of trabecular bone in the epiphysis and metaphysis regions also decreased in MSG-treated rats, together with an increase of adipose tissue in the bone marrow.