Cartilage-forming Tumors at Multiple Sites in Two B6C3F₁ Mice

抄録

Multiple chondromas were observed in one young adult (18 weeks old) male B6C3F₁ strain mouse used in toxicity tests for safety assessment of chemicals. Solitary chondroma composed of mature cartilage cells was found in different sites of the ribs. In addition, chondrosarcoma was observed in the lumbar vertebra and abdominal cavity of one old (109 weeks old) male mouse of the same strain. The sarcoma was composed of mixed atypical chondrocytic and spindle-shaped cells, extending into the surrounding tissue. This is a report on spontaneous multiple chondromas occurring in the B6C3F₁ mouse.