Abstract
Craniopharyngeal duct cysts were examined in two beagles. Histologically, multiple cysts of various sizes were observed in the pars distalis. They were lined with flattened, cuboidal, or columnar shaped epithelial cells, with or without cilium, whereas the cysts in rats consisted of various shaped epithelial structures, such as tubular, mucous glandular, or fusiform. Immunohistochemically, the epithelial cells of the cysts were found to express epithelial markers. The morphological findings indicated that they originated from the stomatodeum, but not that the cystic epithelia obviously differentiated into the salivary gland.