Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Case Reports
Lymphoid Hyperplasia of the Spleen of an 8-Week-Old Rat
Satomi NishikawaMiyoko OkadaTetsuya SakairiItsuko IkedaShin KohgeKan TakagiJiro SugimotoFumiko SanoShiro Takagi
著者情報
キーワード: lymphoid hyperplasia, spleen, rat
ジャーナル フリー

2008 年 21 巻 4 号 p. 243-247

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抄録
In a young adult (8 weeks old) Sprague-Dawley (SD) rat, a 7 mm-diameter hemispherical nodule with white spots was macroscopically identified on the visceral surface of the spleen. Microscopically, the nodule consisted of areas of enlarged white pulp. The periarteriolar lymphoid sheaths (PALS) area was expanded due to an increase in lymphocytes, but the marginal zone was relatively atrophied. Although minimal compressions and mitotic figures were sporadically observed, there were no structural alterations or atypical cells. Immunohistochemically, there were increased numbers of proliferating cells (Ki-67 positive cells) in the PALS and red pulp areas. In the PALS area, there were increased numbers of T-cells and macrophage/dendritic cells, while in the red pulp area, there were increased numbers of T-cells and B-cell/plasma cells. This lesion, which is believed to be hyperplastic and not neoplastic, was diagnosed as lymphoid hyperplasia, a condition considered to be uncommon in young adult SD rats.
著者関連情報
© 2008 The Japanese Society of Toxicologic Pathology
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