抄録
Liver cell necrosis was caused in beagle dogs, whose blood in amount of one to two percent of the bodyweight was removed almost everyday for 6 weeks and their hematocrit values were approximately 10% at necropsy time. When animals are in a severe anemic condition attributable to drug administration in toxicological studies, anemia should be considered as a causative factor of liver damage in addition to the possibility of the direct effect of chemicals on the liver.
