抄録
The pancreas and liver of SZ-induced diabetic mice were histopathologically examined up to 4 weeks after the intraperitoneal injection of SZ (200mg/kg). In the pancreas, degeneration of islet, β cells associated with insulitis was prominent in the early stage while a decrease in the size of the islet became predominant in the later stage. On the other hand, scattered minimal foci of hepatocellular necrosis and moderate mononuclear cell infiltration in the portal area were the main hepatic changes in the early stage. In the later stage, prominent hypertrophy of hepatocytes due to an increase in intracytoplasmic acidophilic granules was conspicuous. In coincidence with the light microscopic findings, the most characteristic ultrastructural hepatocellular alteration in the later stage was a marked increase in number of swollen mitochondria. In these hepatocytes, depletion of glycogen granules and rough endoplasmic reticula were also observed.
