主催: 日本毒性学会
Zinc oxide nanoparticles (ZnO) are used in an increasing number of industrial products such as paint, coating, cosmetics and other biological application. However, there is not enough information regarding the safety issue. Therefore, this study was designed to investigate the potential harmful effects of ZnO in normal skin using murine normal cell (JB6 Cl 41-5a). Our results showed that ZnO induced reactive oxygen species (ROS). Such increased ROS was closely associated with autophagy induction together with mitochondrial damage. We strongly suggested that ZnO nanoparticle may cause toxicity, thus, careful regulation for ZnO production as well as application should be needed.
