主催: 日本毒性学会
Viral-induced infectious diseases represent a major health threat and their control remains an unachieved goal, duein part to the limited availability of effective anti-viral drugs and measures. The use of natural products in drug manufacturing is an ancient and well-established practice Acer tegmentosum is a type of deciduous tree that grows in Korea. It has been used in traditional medicine for the treatment of hepatic disorders, such as hepatitis, hepatic cancer, and hepatic cirrhosis. In this study, we report on the antiviral potency of an aqueous or ethanol extract of stem of Acer tegmentosum (At-AE or At-EE) against herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus (VZV) in cell culture (Vero and MRC-5 cells) using a plaque reduction and MTT assay. Hydroalcoholic extracts of Acer tegmentosum were phytochemically characterized by HPLC-MS analyses. Pretreatment of Vero cells with At-AE or At-EE significantly reduced HSV-induced cell death. At-AE or At-EE exhibited high levels of antiviral activity against both types of herpesvirus in a dose-dependent manner. At maximum noncytotoxic concentrations of the extract, plaque formation was significantly reduced by At-AE or At-EE for HSV-1 and HSV-2, and VZV in a concentration-dependent manner. Hence this extract is capable of exerting an antiviral effect on herpes simplex virus and might be suitable for topical therapeutic use as antiviral drug both in labial and genital herpes infection.
Keywords: Acer tegmentosum; Antiviral; herpes simplex virus; varicella zoster virus
