抄録
A549 and H460 cells are representative cell lines of NSCLC with the same histology and great differences in invasive behavior as well as in response to ionizing radiation exist between two cell lines. Because these cell lines exhibit an intrinsic resistant difference to both radiotherapy and chemotherapy, in this study, we showed that a variety of genes, highly differently expressed by methylation extent of promoter region of this gene in A549 and H460 cells, modulates cell growth, metastasis and sensitization of cells to the detrimental effects of damaging agents such as γ-radiation Therefore, through the genome-wide screening, it is necessary to determine appropriate candidate genes involved in the radiation resistant characteristics to improve therapeutical efficiency and thus result in reduction of malformation risk of normal. EFEMP1, ALDH1, TSPYL5, SM22α and TM4SF4 are representative genes and proteins that determine the characteristics of cancer stem cell like cells. [The Authors wish to acknowledge the financial support of the Ministry of Education, Science and Technology (Nuclear Research & Development program) of the Republic of Korea)
